![]() We define “forgetting”, for present purposes, as simply the inability to recall information that was once recalled previously. Recent evidence has demonstrated that adult neurogenesis mediates forgetting of existing memories. Only recently has significant attention been paid to the retrograde effects of adult neurogenesis on existing memories. ![]() Ablation of adult neurogenesis, or impairing the synaptic integration of adult-born neurons, impairs the acquisition of new memories and enhancement of neurogenesis improves subsequent learning. Hippocampal neurogenesis plays a critical role in long-term memory, but its precise roles are not fully understood. These results suggest that forgetting due to neurogenesis is a conserved mechanism that aids in the clearance of memories. Even with a very strong training protocol in the CFC task, we still observed enhanced forgetting related to increased neurogenesis. In addition, we asked whether stronger memories are less susceptible to forgetting by varying the strength of training. We show that voluntary running causes forgetting of context fear memories in a neurogenesis-dependent manner, and that neurogenesis-induced forgetting is present in rats across behavioral tasks despite differences in complexity or reliance on spatial, context, or object memories. Neurogenesis was increased following training using voluntary exercise for 4 weeks before recall of the previous memory was assessed. Here, we investigated whether neurogenesis-induced forgetting occurs in rats using several hippocampus-dependent tasks including contextual fear conditioning (CFC), the Morris Water Task (MWT), and touchscreen paired associates learning (PAL). Although a general species difference is possible, other potential explanations for these incongruent findings are that memories which are more strongly reinforced become resilient to forgetting or that perhaps only certain types of memories are affected. Neurogenesis-induced forgetting was originally demonstrated in mice, but a recent report suggests that the same effect may be absent in rats. Recent studies demonstrate that increasing neurogenesis after memory formation induces forgetting of previously acquired memories. The formation and retention of hippocampus-dependent memories is impacted by neurogenesis, a process that involves the production of new neurons in the dentate gyrus of the hippocampus.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |